A triple-threat guitarist, harp blower, and vocalist, Dr. Ross decided to fire his sidemen and carry on as a one-man band, a tradition that also includes Joe Hill Louis, Daddy Stovepipe, and Jesse Fuller. Ross' music did not depend on novelty effect, yet it had a distinctly recognizable sound, in part because he learned to play his own way and essentially played everything backwards. His guitar was tuned to open G (like John Lee Hooker and other Delta artists), but Ross played it left-handed and upside-down. He also played harmonica in a rack, but it was turned around with the low notes to the right. As an instrumentalist, Ross perfected the interplay between guitar and harmonica.